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Inventi Impact: Obstetrics and Gynaecology

Articles

  • Inventi:hog/31268/20
    Importance of the Glycated Hemoglobin Assay in Congolese Women with Polycystic Ovary Syndrome: A Case-Control Study in Kinshasa, DR Congo
    Research 2020 : April - June
    Daddy Kabamba Numbi, Dophie Tshibuela Beya, Guelord Mukiapini Luzolo, Passy Kimena Nyota, Placide Cyanga Ngandu, Mamy Ngole Zita, Gustave Ilunga Ntita, Donatien Kayembe Nzongola-Nkasu, Jérémie Muwonga Masidi, Mireille Nganga Nkanga, Justin Mboloko Esimo, Arsène Mputu Lobota, Jean Bosco Kasiam Onkin, Baudouin Buassa-bu-Tsumbu, Cathy Ali Risasi, Fons Verdonck, Bernard Spitz, Jean Pierre Elongi Moyene

    Context: Polycystic ovary syndrome (PCOS) is considered a syndrome related\nto the metabolic syndrome with a high risk for developing diabetes mellitus.\nThe evaluation of the glycated hemoglobin (HbA1c) seems to be an interesting\ntool to detect states of hyperglycemia that may be associated with this\nsyndrome and to understand her pathophysiology. Aims: The purposes of\nthis study are to determine the profile of HbA1c in Congolese women with\nPCOS, to determine the frequency of states of hyperglycemia and to assess the\nimpact of this marker on clinical signs on this syndrome. Material and methods:\nThis is a case-control study of 130 Congolese subfertile women; 65\nwith a diagnosis of PCOS and 65 others without PCOS. This is conducted\nfrom June 2016 to June 2019 among Congolese women of childbearing age.\nAll these women were recruited at the subfertility outpatient clinic of the\nUniversity Hospital of UNIKIN as well of the YANGA medical centers in\nKinshasa, Democratic Republic of Congo. Sickle cell disease was excluded as\nalso the cases of anemia. HbA1c was assayed via the immunoturbidimetric\nmethod and the results interpreted according to the ADA recommendations\nwith a pathological cut-off point greater than equal to 6.5%. Results: Mean hemoglobin was 11.6 }\n1.2 g/dl (11.5 } 1.1 g/dl vs. 11.8 } 1.4 g/dl, P = 0.568). The proportion of diabetics\nwas 1.6% (1.6% vs. 1.5%, P = 0.74). Higher HbA1c values were noted\nin the PCOS group compared to the control group (7.3% } 2.1% vs. 5.6% }\n0.6%, P < 0.001). The multivariate analysis showed a strong correlation between\nelevated HbA1c levels and PCOS (OR 14.79 (CI 5.43 - 40.32), P <\n0.001). In the PCOS group, higher HbA1c values were significantly correlated\nwith a higher socio-economic status (OR 3.38 (1.67 - 8.47), P = 0.018) and\nwith obesity (OR 3.48 IC (1.31 - 7.13) P = 0.029). A perfect, positive and significant\nlinear correlation was found between HbA1c and fasting blood glucose\n(r = 0.807). 60% of women in the PCOS group had pathological values of\nHbA1c (greater than equal to 6.5%) compared to 7.7% in the control group (P < 0.001). Oligomenorrhea\nwas found more significantly in patients with pathological HbA1c\nvalues (greater than equal to 6.5%) compared to those with values < 6.5% (P = 0.003). Conclusion:\nThis study found that in our population 60% of women with PCOS had\nstates of hyperglycemia, demanding systematic screening of glucose metabolism\ndisorders in women with this syndrome.

    How to Cite this Article
    Attribution/ CC Compliant Citation: Numbi, D.K., Beya, D.T., Luzolo, G.M., Nyota, P.K., Ngandu, P.C., Zita, M.N., Ntita, G.I., Nzongola-\nNkasu, D.K., Masidi, J.M., Nkanga, M.N., Esimo, J.M., Lobota, A.M., Onkin, J.B.K., Buassa- bu-Tsumbu, B., Risasi, C.A., Verdonck, F., Spitz, B.\nand Moyene, J.P.E. (2019) Importance of the Glycated Hemoglobin Assay in Congolese Women with Polycystic Ovary Syndrome: A\nCase-Control Study in Kinshasa, DR Congo. Open Journal of Obstetrics and Gynecology, 9, 1492-1509.\nhttps://doi.org/10.4236/ojog.2019.911145\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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